Turkey Tetrazzini is a comforting, creamy pasta casserole that’s perfect for using up leftover turkey. Originating in early 20th-century America, this dish blends cooked turkey with spaghetti, mushrooms, and a rich cream sauce, all baked under a golden crust of cheese or breadcrumbs.
Its velvety texture and savory flavor make it a family favorite, especially around the holidays. Versatile and easy to customize, Turkey Tetrazzini can also include peas, onions, or other vegetables.
Whether made fresh or with leftovers, it delivers satisfying, home-cooked goodness in every bite. It’s the ultimate blend of Italian inspiration and American comfort food tradition.
Turkey Tetrazzini is a classic American pasta casserole that brings comfort and flavor to the table, particularly when you have leftover turkey from the holidays. Named after Italian opera star Luisa Tetrazzini, this dish has its roots in early 20th-century American cuisine.
Despite its Italian-sounding name, it is an all-American creation—a creamy, cheesy, and hearty bake that combines turkey, pasta, mushrooms, and a velvety sauce, all topped with a golden crust.
Perfect for feeding a crowd or enjoying as a make-ahead weeknight dinner, Turkey Tetrazzini is the epitome of cozy, nostalgic food.
Turkey Tetrazzini is a comforting American pasta casserole made with tender cooked turkey, spaghetti, and a creamy mushroom sauce.
Often baked with a golden breadcrumb or cheese topping, this dish is a delicious way to use up leftover turkey.
Flavored with garlic, onions, and a touch of white wine or broth, it brings together rich and savory notes in every bite.
Turkey Tetrazzini is especially popular during the holidays, offering a warm and satisfying meal for family gatherings. It’s hearty, easy to prepare ahead, and perfect for feeding a crowd.
Servings 8
* Percent Daily Values are based on a 2,000 calorie diet. Your daily value may be higher or lower depending on your calorie needs.
Turkey Tetrazzini is a comforting, creamy pasta bake that makes excellent use of leftover turkey, particularly after holidays like Thanksgiving or Christmas.
Made with spaghetti or other long pasta, tender turkey, mushrooms, and a luscious cheese sauce, it's a crowd-pleaser perfect for family dinners or potlucks.
Below are practical tips and serving tricks to help you create the most delicious and well-presented Turkey Tetrazzini every time.
Turkey Tetrazzini is the perfect way to repurpose leftover roast turkey, especially breast meat. However, don’t hesitate to use dark meat or even a mix of both. Just make sure the turkey is shredded or diced into bite-sized pieces.
Boil your pasta just to the al dente stage—this means it's firm to the bite. It will finish cooking in the oven while absorbing the creamy sauce. Overcooked pasta can turn mushy after baking, especially in a creamy dish like this.
Instead of just opening a can of cream soup, make a simple roux-based white sauce with butter, flour, broth, and cream or milk. This creates a richer, more customizable sauce. Add garlic, onions, thyme, and even a splash of white wine or sherry for depth of flavor.
The sauce should be thick enough to coat the back of a spoon but not overly thick. If it’s too thin, the dish will be soupy after baking; if too thick, it will dry out. Adding a little bit of pasta water or turkey broth can help reach the right consistency.
Sautéed mushrooms are traditional, but you can also add peas, spinach, or bell peppers. These vegetables add color, texture, and nutrients. Be sure to pre-cook any veggies that release water, like mushrooms or spinach, to avoid a watery casserole.
Parmesan adds sharpness, while mozzarella or Monterey Jack brings meltiness. Avoid using only pre-shredded cheese as it often contains anti-caking agents that can affect texture. For extra indulgence, consider a sprinkle of Gruyère or sharp cheddar.
A topping of buttered breadcrumbs, crushed crackers (like Ritz), or even panko mixed with parmesan gives the dish a golden, crispy finish. Bake uncovered for the final 10-15 minutes to ensure a crispy topping.
Instead of a single casserole, divide the Tetrazzini into individual ramekins or mini cast-iron skillets. This gives a restaurant-style feel and ensures everyone gets a bit of crispy topping in each serving.
Sprinkle chopped parsley or fresh thyme over the top just before serving. This adds color and a fresh note that balances the richness of the dish.
Since Turkey Tetrazzini is creamy and filling, serve it with a crisp green salad, lemony steamed green beans, or roasted Brussels sprouts to lighten the meal and offer contrast.
Offer crusty garlic bread, sourdough, or soft dinner rolls on the side. They’re great for scooping up extra sauce and make the meal feel complete.
Turkey Tetrazzini can be made ahead and refrigerated for up to 2 days before baking. To reheat leftovers, cover with foil and warm in a 350°F oven until heated through to maintain moisture and texture.
Serve Turkey Tetrazzini with a crisp green salad, garlic bread, or roasted vegetables. It’s a well-rounded dish on its own but pairs wonderfully with something fresh and tangy to cut through the richness.
Turkey Tetrazzini is more than just a leftover makeover—it’s a creamy, cheesy, and satisfying dish that pleases both family and guests.
Turkey Tetrazzini is more than just a leftover dish—it’s a versatile comfort food that can be dressed up or down. With thoughtful prep, smart ingredient swaps, and creative serving tricks, it can become a new family favorite that earns a place in your regular recipe rotation.
Whether made fresh or from holiday remnants, this casserole is sure to become a staple in your comfort food rotation. Its versatility, ease, and nostalgic charm make it a classic worth revisiting time and again.
